About EPA

Dr. Freshteh Toghrol, Director of EPA’s Microarray Research Laboratory

Education and Training

  • Doctor of Philosophy in Biochemistry, University of Southampton, Southampton, England

Professional Experience

  • 2002 to present:  Senior Science Advisor, Director. Microarray Research Laboratory, US EPA, Fort Meade, Maryland
  • 1994 to 2002: Chemist. Office of Pesticide Programs / Biopesticides and Pollution Prevention, US EPA, Arlington, Virginia
  • 1988 to 1994:  Chemist. Office of Pesticide Programs / Health Effect Division, US EPA, Arlington, Virginia
  • 1987 to 1988:  Researcher. National Institutes of Child Development, National Institutes of Health, Bethesda, Maryland

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Selected Publications

  • An Introduction to Biochemistry, Tehran University Press, 1973, Second Edition, 1977 (600 pages translated/edited).
  • H. Jang, C. Nde, F. Toghrol, and W. Bentley (2009). Microarray Analysis of Mycobacterium bovis BCG Revealed Induction of Iron Acquistion Related Genes in Response to Hydrogen peroxide. Environmental Science and Technology (ES&T). Published November 7th, 2009.
  • H. Jang, C. Nde, F. Toghrol, and W. Bentley (2009). “Global Transcriptome Analysis of the Mycobacterium bovis BCG Response to Sodium hypochlorite,” Applied Microbiology and Biotechnology (AMB) Published on September 27th, 2009.
  • C. Nde, H. Jang, F. Toghrol, and W. Bentley (2009). Global Transcriptomic Response of Pseudomonas aeruginosa to Chlorhexidine diacetate. Environmental Science and Technology Journal. Published on September 10th, 2009.
  • Nde, C., Jang, H., Toghrol, F. and Bentley, W. (2008). Toxicogenomic Effects of Ortho-phenyl phenol (OPP) on Pseudomonasaeruginosa. BMC Genomics. Published on Oct. 10 2008.
  • Jang, H., Nde, C., Toghrol, F. and Bentley, W. (2008).Toxicogenomic Effects of Ortho-phenyl phenol (OPP) on Staphylococcusaureus. BMC Genomics. Published on Sep. 15 2008.
  • Jang,  H., Chang, W., Toghrol, F., and Bentley, W. (2007).  Microarray Analysis of Toxicogenomic Effects of Triclosan on Staphylococcus aureus.  Applied Microbiology & Biotechnology. Publication in press (Published on Web 1/22/2008).
  • Chang, W., Toghrol, F., and Bentley, W. (2007). Toxicogenomic  Response to Chlorination Includes Induction of Major Virulence Genes in Staphylococcus aureus.  Environmental Science and Technology. Publication in press (Published on Web 10/05/2007).
  • Small, D., Chang, W., Toghrol, F., and Bentley, W. (2007). Comparative global transcription analysis of sodium hypochlorite, peracetic acid, and hydrogen peroxide on Pseudomonas aeruginosa. Applied Microbiology & Biotechnology, 2007 Oct; 76(5):1093-105
  • Small, D., Chang, W., Toghrol, F., and Bentley, W. (2007). Toxicogenomic Analysis of Sodium hypochlorite Antimicrobial Mechanisms in Pseudomonas aeruginosa.  Applied Microbiology & Biotechnology, 2007 Feb; 74(1):176-85
  • Chang, W., Toghrol, F., and Bentley, W. (2006). Toxicogenomic response of Staphylococcus aureus to peracetic acid. Environmental Science and Technology 40(16) 5124-5131.
  • Chang, W., Small, D., Toghrol, F., and Bentley, W. (2006). Global transcriptome analysis of Staphylococcus aureus response to hydrogen peroxide. Journal of Bacteriology 188(4)1648-1659.
  • Chang, W., Small, D.A., Toghrol, F., and Bentley, W.E. Microarray analysis of Pseudomonas aeruginosa reveals induction of pyocin genes in response to hydrogen peroxide. BMC Genomics 2005, 6(1):115.
  • Chang, W., Small, D.A., Toghrol, F., and Bentley, W.E. Toxicogenomic Effects of Peracetic Acid on Pseudomonas aeruginosa PA01,Environ. Sci. Technol. 2005, 39(15):5893-5899.
  • Toghrol, P., Kimura, T., and Owens, I.S., Expression of UDP-Glucuronosyltransferase cDNA in Saccharomyces Cerevisiae as a Membrane-Bound and as a Cytosolic Form. Biochemistry 1990, 29(9):2349-2356.
  • Toghrol, F., Southerland, W.M. Thiobacillus novellus Sulfite Oxidase: Subunit Structure and Enzymic Cofactors. Fed. Pro. (abstract) 1983, 42:811.
  •  Southerland, W.M., Toghrol, F., Sulfite Oxidase Activity in Thiobacillus novellus. J. Bacteriol. 1983, 56:941-944.
  • Toghrol, F., Southerland, W.M., Purification of Sulfite Oxidase from Thiobacillus novellus: Evidence for Presence of Heme and Molybdenum. J. Bio. Chem. 1983, 256:6762-6766.
  • Southerland, W.M., Akogyeram, C.O., Toghrol, F., Scherrer, R. Interaction of Bisulfite with Unsaturated Fatty Acids. J. Toxicology and Environmental Health 1982, 479-491.
  • Toghrol, F., Johnson, R. Southerland, W.M. Comparison of Thiobacillus novellus and Mammalian Sulfite Oxidase. Fed. Pro. (abstract) 1981, 40:1489.
  • Toghrol, F., Franklin, R.B., Costello, L.C. Citrate Synthesis from Fatty Acids and Amino Acids in Rat Ventral Prostate. Enzyme 1980, 25:371-376.

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