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Computational Toxicology Communities of Practice

EPA's Computational Toxicology Communities of Practice is composed of hundreds of stakeholders from over 50 public and private sector organizations (ranging from EPA, other federal agencies, industry, academic institutions, professional societies, nongovernmental organizations, environmental non-profit groups, state environmental agencies and more) who have an interest in using advances in computational toxicology and exposure science to evaluate the safety of chemicals.

The Communities of Practice is open to the public. Monthly webinars are held at EPA's RTP campus, on the fourth Thursday of the month (occasionally rescheduled in November and December to accommodate holiday schedules), from 11am-Noon EST/EDT. Remote participation is available. For more information or to be added to the meeting email list, contact: Monica Linnenbrink (linnenbrink.monica@epa.gov).

Upcoming Speaker

Topic: An overview of EPA’s Endocrine Disruption Screening Program’s plans for using biological activity data identified through high-throughput screening combined with high-throughput exposure estimates to prioritize chemicals for estrogen-related activity

Who: David Dix, Ph.D. Director of EPA’s Office of Science, Coordination and Policy 

When: April 23, 2015 from 11:00 AM- 12:00 PM 

Where: In person at EPA's Research Triangle Park, or attending via teleconference by joining the meeting email list for call-in information

Computational Toxicology Recent Presentation Files

Presentation Title Presented By Date
Exploring the Potential Utility of High-throughput Bioassays Associated with U.S. EPA ToxCast Program for Effects-based Monitoring and Surveillance  (also view Video) Anthony Schroeder, Postdoctoral Associate, National Health and Environmental Effects Research Laboratory, EPA) 2015/01/22
Highlights of the New ToxCast Data Pipeline Filer, Dayne ORISE Fellow and Richard Judson PhD, US EPA Office of Research and Development (ORD), National Center for Computational Toxicology (NCCT) 2014/12/11
Updates about EPA’s High-Throughput Exposure Prediction Research (ExpoCast) Project  (also view Video) Wambaugh, John, PhD, US EPA ORD, NCCT 2014/11/20
Bioactivity profiling using primary human cell systems in support of predictive toxicology (also view Video) Houck, Keith, PhD, US EPA ORD, NCCT 2014/10/23
An Interspecies Comparison of Toxicity Pathways Mediating Neurodevelopmental Toxicity in Neurospheres - and Novel Computational Approaches for High Content Image Analyses (HCA) (also view Video) Fritsche, Ellen, M.D. from IUF - Leibniz Research Institute of Environmental Medicine, Germany 2014/09/25
Functional Substitution: Advancing Safer Alternatives Through Use-Based Thinking (also view Video) Tickner, Joel, PhD, University of Massachusetts Lowell Department of Community Health and Sustainability 2014/07/31
In Vitro Screening For Inter-Individual and Population Vulnerability in Pesticide Mixtures Abdo, Nour, DVM, MPH, Ph.D. Candidate, Department of Environmental Sciences and Engineering, UNC Chapel Hill 2014/06/26
Developmental Toxicity of Phase I and II ToxCast™ Chemicals to Worms and Fish Boyd, Windy, PhD, National Institute of Environmental Health Sciences (NIEHS) 2014/05/22
Strynar, Mark, PhD, EPA, ORD, National Exposure Research Laboratory (NERL) and Shuang Liang, EPA, ORD, NERL, Research Triangle Park, NC 2014/04/24
RASL-Seq: A Gene Expression Platform to Identify Toxicity Mechanisms and Adaptive Responses (also view Video) Gerhold, David, PhD, National Institutes of Health (NIH), NCATS 2014/03/20
ToxCast: Chemical List(s), Chemical Space, and Chemotype Information (also view Video) Richard, Ann, PhD, US EPA/ORD/NCCT, Research Triangle Park, NC 2014/02/27
Exploring consumer exposure pathways and patterns of use for chemicals in the environment through the Chemical/Product Categories Database (CPCat) (also view Video or listen to Audio - For audio, at the prompt, enter your name and email address, choose your player and click to listen) Dionisio, Kathie, Sc.D., US EPA, ORD NERL, Research Triangle Park, NC 2014/01/23
Chemical Safety for Sustainability Dashboard & ToxCast Phase II Data Release Overview (Video) Martin, Matthew, PhD, US EPA, ORD, NCCT, Research Triangle Park, NC 2013/12/12
Mathematically Simplifying PBPK Mixture Systems LeFew, William, PhD, US EPA, ORD, National Health and Environmental Effects Research Laboratory (NHEERL)/ISTD, Research Triangle Park, NC 2013/11/21
Incorporating Population Variability and Sensitive Subpopulations into Dosimetry for High-Throughput Toxicity Testing (also view Video or listen to Audio - For audio, at the prompt, enter your name and email address, choose your player and click to listen) Wetmore, Barbara , PhD, from the Hamner Institute 2013/10/21
Adverse Outcome Pathway Wiki Edwards, Stephen, US EPA, Research Triangle Park, NC 2013/09/26
A Computational Tool for Defining Conservation of Molecular Initiating Events Across Species LaLone, Carlie, PhD, US EPA, Duluth, MN 2013/08/22
Cheminformatics and Toxicogenomics for Toxicology Prediction and Mechanistic Insight (also view Video or listen to Audio - For audio, at the prompt, enter your name and email address, choose your player and click to listen) Daston, George, Research Fellow at Proctor & Gamble 2013/07/25
High Throughput Heuristics Can Forecast Human Exposure to Environmental Chemicals Wambaugh, John, PhD, US EPA, ORD, NCCT, Research Triangle Park, NC 2013/06/27
Profiling 976 ToxCast Chemicals Across 331 Enzymatic and Receptor Signaling Assays Sipes, Nisha, PhD, US EPA, ORD, NCCT, Research Triangle Park, NC 2013/05/23
T3DB - The Toxin, Toxin-Target Database Wishart, David, PhD, University of Alberta,Edmonton, AB, Canada 2013/04/25
CSS Dashboard Martin, Matthew, PhD, US EPA, ORD, NCCT, Research Triangle Park, NC 2013/03/28
High-Resolution Metabolomics for Environmental Chemical Surveillance and Bioeffect Monitoring Jones, Dean, PhD, Department of Medicine, Emory University 2013/02/28
Application of Computational Toxicology to Prospective and Diagnostic Ecological Risk Assessment Villeneuve, Dan, PhD, Research Toxicologist, US EPA Mid-Continent Ecology Division 2013/01/24
Translating Airway Gene Expression into Biomarkers for Tobacco Smoke Exposure and Lung Cancer Detection Spira, Avrum, M.D., M.Sc., Boston University Medical Center 2012/12/13
Toxicity Screening using Zebrafish Embryos: Form and Function Padilla, Stephanie, PhD, US EPA, ORD, NHEERL 2012/09/27
Quantitative High Throughput Models for Exposure-Based Chemical Prioritization Wambaugh, John, PhD, US EPA, ORD, NCCT,Research Triangle Park, NC 2012/08/23
A freely-available, graphical user interface for ToxPi (Toxicological Prioritization Index) Rusyn, Ivan, MD, PhD, University of North Carolina and David Reif, PhD, US EPA, ORD, NCCT 2012/07/26
State of the Art High-Throughput Approaches to Genotoxicity: Flow Micronucleus, Ames II, GreenScreen and Comet Aardema, Marilyn J., PhD, Chief Scientific Advisor, Toxicology, Leon Stankowski, PhD, Principal Scientist/Program Consultant, and Kamala Pant, Principal Scientist, BioReliance 2012/06/28
Development and Application of In Vitro Models for Screening Drugs and Environmental Chemicals that Predict Toxicity in Animals and Humans McKim, James , PhD, DABT, Founder and Chief Science Officer, CeeTox 2012/05/25
Discovering Environmental Causes of Disease: From Exposure Biology to the Exposome Rappaport, Stephen M., PhD, University of California, Berkeley 2012/04/26
The Texas-Indiana Virtual STAR Center: Zebrafish Models for Developmental Toxicity Screening Bolin, Maria Bondesson, PhD, University of Houston, Center for Nuclear Receptors and Cell Signaling 2012/03/22
Predictive Hepatic Model Systems from Life Technologies: Strateties in Toxicology & Screening Ferguson, Stephen, Life Technologies 2012/01/26
Targeted Testing in Tox21 DeVito, Michael, PhD, National Institute of Environmental Health Sciences 2011/12/25
Vala Sciences Inc: Providing Innovative Strategies for High Content Imaging and Analysis McDonough, Patrick M., PhD/VP of Biological Sciences, Vala Sciences Inc, 2011/11/17
An Interactive Web Application for ToxPi Reif, David M., PhD, US EPA, ORD, NCCT 2012/10/27
ExpoCastDB: A Publicly Accessible Database for Observational Exposure Data Sumit Gangwal, PhD, US EPA, ORD, NCCT 2011/09/22
Computational Toxicology and Prenatal Development Knudsen, Thomas B., PhD, EPA, ORD, NCCT 2011/08/25
Computational Toxicology and High-Throughput Risk Assessment Judson, Richard, US EPA, ORD, NCCT 2011/07/28
Advancing the Next Generation of Risk Assessment Cote, Ila, US EPA, ORD, NCCT 2011/06/23
Predictive Model of Reproductive Toxicity Using ToxCast High Throughput Screening Martin, Matt, US EPA, ORD 2011/05/26
EPA's Computational Toxicology Communities of Practice Series: Using Life Cycle Assessment for Risk Management Curran, Mary Ann, US EPA, ORD 2011/04/28
NTP Workshop: Role of Environmental Chemicals in the Development of Diabetes and Obesity Thayer, Kris, NIEHS/NTP 2011/03/24
Chemical Safety for Sustainability: EPA Research to Meet 21st-Century Needs Morris, Jeff, US EPA 2011/02/24
Experiencing REACH Exposure Assessments Lander, Debbie, E.I, DuPont de Nemours and Company 2011/01/27
Overview of ToxCast Phase II Chemicals Richard, Ann, US EPA 2010/12/16
Toxicant Analysis via High-content Screening of Cellular Circuits Westwick, John, Odyssey Thera 2010/11/18
Chemical Screening Visualization Tool: Resource for Rapid Chemical Assessment Chen, Mario, Dupont 2010/10/28
Comprehensive Exposure Narrative McKoneTom, University of California Los Angeles School of Public Health 2010/09/21

Computational Toxicology Communities of Practice: Older Presentations